IP

Intellectual Property Portfolio

Granted patents in the US, Japan and Russia

PCTS Filed Covering 5 Areas Of Innovation

1

Administration

  • Intranasal ExoPTEN (granted in the US and pending in other countries)
    This covers and protects our Exo-PTEN technology, drug composition, and methods for non-invasive intranasal administration of exosome-based treatment.

2

Exosomes and Large Scale Production

  • 2 PCTs on Production and Composition of Matter of our exosomes
  • 2D and 3D production to achieve exosome potency

3

API

  • Provisional patents describing siRNA sequences to inhibit PTEN production (ExoPTEN)

4

Loading Technology

  • Incubation allows efficient loading
  • No genetic engineering
  • Loading doesn’t interact with cell membrane biochemistry, uses natural pathway that maintains integrity of exosomes
  • Non-toxic, natural conjugate media
  • Loading occurs post-production

5

PNN Protein Inhibition

Term of Patents Overview

Nov. 15, 2024
Nov. 30, 2024
Jan. 10, 2025
Sep. 2039
Jun. 2040
Mar. 2042
PNN Protein Inhibition
siRNA Sequences PTEN Inhibitors with Exosomes

National Phase entry
by Nov. 15, 2024
API
Sugars as API and Loading moieties

National Phase entry
by Nov. 30, 2024
Loading Technology
Inhibition of the PNN proteins

National Phase entry
by Jan. 10, 2025
Administration
Vesicles comprising a PTEN inhibitor and uses of same (WO2019/186558)

Expiry: Sep. 2039

Exosomes and Large Scale Production
Production of extracellular vesicles from stem cells (PCT1) (WO2020/261257)

Potential expiry: Jun. 2040
Exosomes and Large Scale Production
Production of extracellular vesicles from stem cells (PCT2) (WO2022/190091)

Potential expiry: Mar. 2042

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