The study conducted at Prof. Shulamit Levenberg laboratory at the Technion, Haifa in collaboration with Prof. Danny Offen from Tel Aviv University presented intranasal administrations of MSC derived exosomes loaded with PTEN-siRNA (ExoPTEN), which targeted spinal cord lesions in rats with complete SCI and enabled significant functional recovery.
The article describing the study and its results can be found online at:
Exosomes derived from mesenchymal stem cells improved core symptoms of genetically modified mouse model of autism Shank3B
Perets N, Oron O, Herman S, Elliott E, Offen D.Mol Autism. 2020 Aug 17;11(1):65.
Intranasal Delivery of Mesenchymal Stem Cell Derived Exosomes Loaded with Phosphatase and Tensin Homolog siRNA Repairs Complete Spinal Cord Injury
Guo S, Perets N, Betzer O, Ben-Shaul S, Sheinin A, Michaelevski I, Popovtzer R, Offen D, Levenberg S.ACS Nano. 2019 Sep 24;13(9):10015-10028.
Golden Exosomes Selectively Target Brain Pathologies in Neurodegenerative and Neurodevelopmental Disorders
Perets N, Betzer O, Shapira R, Brenstein S, Angel A, Sadan T, Ashery U, Popovtzer R, Offen D.Nano Lett. 2019 Jun 12;19(6):3422-3431.
Intranasal administration of exosomes derived from mesenchymal stem cells ameliorates autistic-like behaviors of BTBR mice
Perets N, Hertz S, London M, Offen D.Mol Autism. 2018 Nov 21;9:57.
In Vivo Neuroimaging of Exosomes Using Gold Nanoparticles
Betzer O, Perets N, Angel A, Motiei M, Sadan T, Yadid G, Offen D, Popovtzer R.ACS Nano. 2017 Nov 28;11(11):10883-10893.