Exosomes, a key element of ExoTherapy, are derived from stem cells in bio-production processes. The Technion-developed process suggests that shear stress stimulation of stem cells during Three-Dimensional (3D) exosome production yields both increased secretion of exosomes and enhanced exosome potency. NurExone carried out a pilot study of the shear stress production process assessing productivity and quality outcomes under different flow regimes, compared to controls produced using current two-dimensional (2D) or state-of-the-art 3D production techniques.